OPTIMIZATION OF A CULTURE-MEDIUM FOR STREPTOMYCIN PRODUCTION USING RESPONSE-SURFACE METHODOLOGY

被引：24

作者：

SAVAL, S ^{[1
]}

PABLOS, L ^{[1
]}

SANCHEZ, S ^{[1
]}

机构：

[1] NATL AUTONOMOUS UNIV MEXICO,FAC VET MED & ZOOTECH,DEPT GENET & STAT,MEXICO CITY,DF,MEXICO

来源：

BIORESOURCE TECHNOLOGY | 1993年 / 43卷 / 01期

关键词：

STREPTOMYCIN; OPTIMIZATION OF CULTURE MEDIUM; RESPONSE-SURFACE METHODOLOGY; EXPERIMENTAL DESIGN;

D O I：

10.1016/0960-8524(93)90077-O

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

The effects of all ingredients of a culture medium designed for streptomycin production were evaluated in order to select the variables which influenced antibiotic production. Among them, glucose, beer-yeast autolyzate, sodium chloride and dibasic potassium phosphate showed a substantial effect on this parameter and were therefore selected. The optimum concentration for each variable was determined using an orthogonal-central composite experimental design and the response-surface methodology. The determination coefficient (R2) of the fitted second-order model was 0.9384. Applying this model, the optimum concentration of the four variables was obtained and with this optimized medium the streptomycin titre was increased by 52% with respect to the original medium, using an industrial strain of Streptomyces griseus.

引用

页码：19 / 25

页数：7

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