A FACILE, PRACTICAL SYNTHESIS OF 2-(6-METHOXY-2-NAPHTHYL)PROPENOIC ACID

被引：43
|
作者：
HIYAMA, T
WAKASA, N
UEDA, T
KUSUMOTO, T
机构：
来源：
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1990年 / 63卷 / 02期
关键词：
D O I：
10.1246/bcsj.63.640
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile and practical method for the synthesis of 2-(6-methoxy-2-naphthyl)propenoic acid, a precursor of anti-inflammatory agent naproxen, is described. The method involves (1) Pd-catalyzed ethynylation of 2-bromo-6-methoxynaphthalene, (2) regioselective addition of HX to the triple bond, and (3) Pd-catalyzed carbonylation of the resulting vinyl halide followed by (4) alkaline hydrolysis.
引用
收藏
页码：640 / 642
页数：3
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