Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs

被引：9

作者：

Gul Seker, Mine ^{[1
]}

Akbal, Tugce ^{[2
]}

Atilla, Devrim ^{[2
]}

Avsar, Neslihan ^{[2
]}

Ibisoglu, Hanife ^{[2
]}

机构：

[1] Gebze Tech Univ, Fac Sci, Dept Mol Biol & Genet, TR-41400 Gebze, Kocaeli, Turkey

[2] Gebze Tech Univ, Fac Sci, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey

来源：

JOURNAL OF RESEARCH IN PHARMACY | 2018年 / 22卷 / 04期

关键词：

Antimicrobial activity; mininimal inhibition concentration; phosphazene; curcumin;

D O I：

10.12991/jrp.2018.95

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Six novel bridged structure cyclotriphosphazenes (4a-f) were synthesized from the reactions of aryloxycyclotriphosphazenes [aryloxy= phenoxy (2a) and (2-naphthoxy) (2b)] with monocarbonyl curcumin derivatives [acetone (3a), cyclopentanone (3b) and cyclohexanone (3c)] for the first time. The structures of the compounds (4a-f) were defined by elemental analysis, FT-IR, mass and NMR (H-1 and P-31) spectroscopies. The antimicrobial properties of the compounds (2a, 2b, 3a-c and 4a-f) were screened in vitro against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Bacillus cereus DSMZ 4312 and Candida albicans ATCC 10231. In addition, effective substance of 3b and 4c were evaluated Minimal Inhibition Concentration.

引用

页码：536 / 546

页数：11

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