Contribution of Helicobacter pylori Infection to Eukaryotic Cell-Cycle Arrest

被引：0

作者：

Anikeenok, M. O. ^{[1
]}

Ilinskaya, O. N. ^{[1
,2
,3
]}

机构：

[1] Kazan VI Lenin State Univ, Dept Microbiol, Kazan, Russia

[2] Kazan VI Lenin State Univ, Biol Sci, Kazan, Russia

[3] Kazan VI Lenin State Univ, Kazan, Russia

来源：

UCHENYE ZAPISKI KAZANSKOGO UNIVERSITETA-SERIYA ESTESTVENNYE NAUKI | 2009年 / 151卷 / 04期

关键词：

Helicobacter pylori; ATM/ATR - signaling pathway; phosphorylation; kinase;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Helicobacter pylori infection plays an important role in the development of gastric adenocarcinoma in humans. Therefore, it is necessary to investigate reparation, apoptosis and cell-cycle regulation in the pathogen-affected cells. The article regards the activation of ATM-kinase substrates Chk2 and p53 in eukaryotic cells after infection with H. pylori P12. It is stated that infection leads to phosphorylation of Chk2 by the kinase, different from ATM in HeLa and AGS cells. At the same time, activation of p53, one of the substrates of Chk2, is not detected.

引用

页码：67 / 73

页数：7

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