WBN/KOB RAT - A NEW MODEL OF SPONTANEOUS DIABETES, OSTEOPENIA AND SYSTEMIC HEMOSIDERIN DEPOSITION

被引:9
|
作者
IGARASHI, C
MARUYAMA, T
EZAWA, I
TAKEI, I
SARUTA, T
机构
[1] JAPAN WOMENS UNIV, DEPT FOOD & NUTR, BUNKYO KU, TOKYO 112, JAPAN
[2] KEIO UNIV, SCH MED, DEPT INTERNAL MED, TOKYO, JAPAN
来源
BONE AND MINERAL | 1994年 / 27卷 / 02期
关键词
DIABETES-MELLITUS; WBN/KOB RAT; OSTEOPENIA; VITAMIN-D METABOLITES; HEMOSIDEROSIS;
D O I
10.1016/S0169-6009(08)80215-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A long-term investigation of bone mineral metabolism in a newly developed strain, the WBN/Kob rat, which spontaneously develops diabetes, possibly due in part to hemosiderin deposition, was conducted. WBN/Kob rats used in this study developed diabetes after 9 months of age, Bone mass peaked at 6 months or 8 months of age, and femoral breaking strength was maximal at 8 months of age, declining rapidly after the development of diabetes. In contrast, both the bone mass and the mechanical strength increased up to 14 months of age in controls, The serum osteocalcin (BGP) levels were lower at 4 months of age and serum 1,25(OH)(2)D levels were significantly lower throughout the study in WBN/Kob rats than in controls. These results suggest that abnormal bone and mineral metabolism is present in WBN/Kob rats before the onset of diabetes, and that bone strength and BMD decrease simultaneously with the development of diabetes, This strain can serve as a useful model, not only of hemosiderosis and diabetes, but also of osteopenia.
引用
收藏
页码:133 / 144
页数:12
相关论文
共 50 条
  • [21] A NEW DIABETIC STRAIN OF RAT (WBN/KOB) - THE MODE AND PATHO-PHYSIOLOGY OF PANCREATIC IMPAIRMENT
    YOKOYAMA, J
    MORI, Y
    NISHIMURA, M
    KURATA, H
    SASAKI, A
    SAKAMOTO, Y
    TAJIMA, N
    IKEDA, Y
    DIABETOLOGIA, 1988, 31 (07) : A561 - A561
  • [22] EFFECTS OF ALDOSE REDUCTASE INHIBITOR ON THE RENAL AND NEURAL LESIONS IN A NEW DIABETIC STRAIN OF RAT (WBN KOB)
    MORI, Y
    YOKOYAMA, J
    NISHIMURA, M
    SASAKI, A
    SAKAMOTO, Y
    TSURUOKA, A
    KURATA, H
    MIURA, J
    IKEDA, Y
    DIABETOLOGIA, 1989, 32 (07) : A519 - A519
  • [23] Osteopenia in a Spontaneous Mouse Model of Systemic Lupus Erythematosus
    Lotinun, Sutada
    Atjanasuppat, Korakot
    Visitchanakun, Peerapat
    Saiworn, Worasit
    Pisitkun, Prapaporn
    Leelahavanichkul, Asada
    FASEB JOURNAL, 2018, 32 (01):
  • [24] Syphacia muris infection delays the onset of hyperglycemia in WBN/Kob-Leprfa rats, a new type 2 diabetes mellitus model
    Taira, K.
    Yazawa, R.
    Watanabe, A.
    Ishikawa, Y.
    Okamoto, M.
    Takahashi, A.
    Asai, F.
    HELMINTHOLOGIA, 2015, 52 (01) : 58 - 62
  • [25] Specific Hemosiderin Deposition in the Spleen of TSOD Mice - A Unique Spontaneous Model Showing Obesity, Diabetes, Hyperlipidemia, and Steatohepatitis
    Nishida, T.
    Tsuneyama, K.
    Nomoto, K.
    Hayashi, S.
    Miwa, S.
    Nakajima, T.
    Nakanishi, Y.
    Imura, J.
    LABORATORY INVESTIGATION, 2013, 93 : 444A - 444A
  • [26] Expression of tumor necrosis factor-α, interleukin-6, and interferon-γ in spontaneous chronic pancreatitis in the WBN/Kob rat
    Xie, MJ
    Motoo, Y
    Su, SB
    Sawabu, N
    PANCREAS, 2001, 22 (04) : 400 - 408
  • [27] Specific Hemosiderin Deposition in the Spleen of TSOD Mice - A Unique Spontaneous Model Showing Obesity, Diabetes, Hyperlipidemia, and Steatohepatitis
    Nishida, T.
    Tsuneyama, K.
    Nomoto, K.
    Hayashi, S.
    Miwa, S.
    Nakajima, T.
    Nakanishi, Y.
    Imura, J.
    MODERN PATHOLOGY, 2013, 26 : 444A - 444A
  • [28] Inflammation and fibrosis are sequentally inhibited by a COX-2 inhibitor in a rat model (WBN/Kob) of chronic pancreatitis
    Reding, T
    Perren, A
    Sun, LK
    Fortunato, F
    Bimmler, D
    Graf, R
    GASTROENTEROLOGY, 2005, 128 (04) : A378 - A378
  • [29] Effects of a human glucagon-like peptide-1 analog in the WBN/Kob-Leprfa rat, a novel type 2 diabetes model
    Nagakubo, Dai
    Nakamura, Yuki
    Arisato, Chika
    Takasugi, Ayami
    Watanabe, Sena
    Kaji, Noriyuki
    Shirai, Mitsuyuki
    Asai, Fumitoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118 : 215P - 215P
  • [30] Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and hyperglycemia in the WBN/Kob-Leprfa rat, a new model of type 2 diabetes mellitus
    Namekawa, Junichi
    Takagi, Yoshiichi
    Wakabayashi, Kaoru
    Nakamura, Yuki
    Watanabe, Ayaka
    Nagakubo, Dai
    Shirai, Mitsuyuki
    Asai, Fumitoshi
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 2017, 79 (06): : 988 - 991