THE FIRST CONVERGENT SYNTHESIS OF 1-ALPHA,24(R)-DIHYDROXYVITAMIN D-3 VIA DIASTEREOSELECTIVE ISOPROPYLATION AND ALKYLATIVE ENYNE CYCLIZATION

被引：16

作者：

OKAMOTO, M ^{[1
]}

FUJII, T ^{[1
]}

TANAKA, T ^{[1
]}

机构：

[1] TEIJIN LTD,CHEM MFG PLANT,IWAKUNI PHARMACEUT FACTORY,IWAKUNI,YAMAGUCHI 740,JAPAN

来源：

TETRAHEDRON | 1995年 / 51卷 / 19期

关键词：

D O I：

10.1016/0040-4020(95)00243-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient covergent synthesis of 1 alpha,24(R)-dihydroxyvitamin D-3 (1) has been achieved using the palladium-catalyzed alkylative enyne cyclization reaction. This is the first example of the convergent coupling procedure to synthesize 1 alpha,24(R)-dihydroxyvitamin D-3 (1). The CD-ring synthons were successfully obtained via the diastereoselective addition of diisopropylzinc to CD-ring 24-aldehyde precursors in the presence of a chiral beta-amino alcohol with high diastereoselectivities

引用

页码：5543 / 5556

页数：14

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