2-(AMINOMETHYL)PHENOLS, A NEW CLASS OF SALURETIC AGENTS .2. SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF THE 5-AZA ISOSTERE OF 2-(AMINOMETHYL)-4-(1,1-DIMETHYLETHYL)-6-IODOPHENOL

被引:7
|
作者
STOKKER, GE [1 ]
SMITH, RL [1 ]
CRAGOE, EJ [1 ]
LUDDEN, CT [1 ]
RUSSO, HF [1 ]
SWEET, CS [1 ]
WATSON, LS [1 ]
机构
[1] MERCK INST THERAPEUT RES,W POINT,PA 19486
关键词
D O I
10.1021/jm00133a024
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:115 / 117
页数:3
相关论文
共 50 条
  • [1] PHYSIOLOGICAL DISPOSITION AND METABOLISM OF 2-AMINOMETHYL-4-(1,1-DIMETHYLETHYL)-6-IODOPHENOL HYDROCHLORIDE
    TOCCO, DJ
    DELUNA, FA
    DUNCAN, AEW
    WALKER, RW
    ARISON, BH
    VANDENHEUVEL, WJA
    DRUG METABOLISM AND DISPOSITION, 1979, 7 (05) : 330 - 334
  • [2] DIURETIC RESPONSE IN NORMAL VOLUNTEERS TO A NEW BENZYLAMINE, 2-AMINOMETHYL-4-(1,1-DIMETHYLETHYL)-6-IODOPHENOL HCL
    LOWENTHAL, DT
    ONESTI, G
    AFFRIME, MB
    SCHROGIE, JJ
    KIM, KE
    BUSBY, P
    SWARTZ, CD
    JOURNAL OF CLINICAL PHARMACOLOGY, 1978, 18 (8-9): : 414 - 424
  • [3] 2-(AMINOMETHYL)PHENOLS, A NEW CLASS OF SALURETIC AGENTS .1. EFFECTS OF NUCLEAR SUBSTITUTION
    STOKKER, GE
    DEANA, AA
    DESOLMS, SJ
    SCHULTZ, EM
    SMITH, RL
    CRAGOE, EJ
    BAER, JE
    LUDDEN, CT
    RUSSO, HF
    SCRIABINE, A
    SWEET, CS
    WATSON, LS
    JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (12) : 1414 - 1427
  • [4] 2-(AMINOMETHYL)PHENOLS, A NEW CLASS OF SALURETIC AGENTS .5. FUSED-RING ANALOGS
    DEANA, AA
    STOKKER, GE
    SCHULTZ, EM
    SMITH, RL
    CRAGOE, EJ
    RUSSO, HF
    WATSON, LS
    JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (04) : 580 - 585
  • [5] 2-(AMINOMETHYL)PHENOLS, A NEW CLASS OF SALURETIC AGENTS .4. EFFECTS OF OXYGEN AND OR NITROGEN SUBSTITUTION
    STOKKER, GE
    DEANA, AA
    DESOLMS, SJ
    SCHULTZ, EM
    SMITH, RL
    CRAGOE, EJ
    BAER, JE
    RUSSO, HF
    WATSON, LS
    JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (06) : 735 - 742
  • [6] MICROPUNCTURE EVALUATION OF THE SITE OF ACTION OF 2-AMINOMETHYL-4-(1,1-DIMETHYLETHYL)-6-IODOPHENOL HYDROCHLORIDE (MK447) IN THE RAT-KIDNEY
    JOHNSTON, PA
    KAU, ST
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1991, 256 (02): : 587 - 591
  • [7] SYNTHESIS AND TRANSFORMATIONS OF 2,6-BIS(1,1-DIMETHYLETHYL)-4-[2-(THAZOLYL)ETHENYL]PHENOLS
    UNANGST, PC
    CONNOR, DT
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1992, 29 (05) : 1097 - 1100
  • [8] 2-(AMINOMETHYL)PHENOLS, A NEW CLASS OF SALURETIC AGENTS .6. EFFECTS OF N,O-SPIROANNULATION AND SUBSEQUENT QUATERNIZATION
    STOKKER, GE
    SCHULTZ, EM
    SMITH, RL
    CRAGOE, EJ
    RUSSO, HF
    WATSON, LS
    LUDDEN, CT
    SWEET, CS
    JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (04) : 585 - 590
  • [9] 2-(AMINOMETHYL)PHENOLS, A NEW CLASS OF SALURETIC AGENTS .3. EFFECTS OF FUNCTIONAL-GROUP REORIENTATION AND MODIFICATION
    STOKKER, GE
    DEANA, AA
    DESOLMS, SJ
    SCHULTZ, EM
    SMITH, RL
    CRAGOE, EJ
    BAER, JE
    RUSSO, HF
    WATSON, LS
    JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (09) : 1063 - 1067
  • [10] METAL-COMPLEXES OF ANTI-INFLAMMATORY DRUGS .6. 2-AMINOMETHYL-4(1,1-DIMETHYLETHYL)-6-IODOPHENOL (MK-447) COMPLEX OF COPPER(II)
    BURY, A
    UNDERHILL, AE
    FLEET, MB
    KEYMER, PJ
    STEVENS, A
    GOMM, PS
    INORGANICA CHIMICA ACTA, 1989, 158 (02) : 181 - 184