STIMULATION OF BOTH D1-DOPAMINE AND D2-DOPAMINE RECEPTORS INCREASES BEHAVIORAL ACTIVATION AND ASCORBATE RELEASE IN THE NEOSTRIATUM OF FREELY MOVING RATS

被引：39
|
作者：
PIERCE, RC [1 ]
REBEC, GV [1 ]
机构：
[1] INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI,BLOOMINGTON,IN 47405
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 191卷 / 03期
基金：
美国国家科学基金会;
关键词：
AMPHETAMINE; ASCORBATE; GBR-12909; NEOSTRIATUM; QUINPIROLE; SK-AND-F-38393; VOLTAMMETRY (INVIVO);
D O I：
10.1016/0014-2999(90)94161-P
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Electrochemically modified carbon-fiber electrodes were used to assess the effects of indirect (amphetamine and GBR-1209) as well as direct D1 (SKF-38393) and D2 (quinpirole) dopamine agonists on extracellular ascorbate in the neostriatum of awake, behaving rats. Relative to controls, 2.5 mg/kg d-amphetamine and 20.0 mg/kg GBR-12909 produced marked behavioral activation concomitant with a significant increase in ascorbate. Comparable effects were observed following the combined administration of 10.0 mg/kg SKF-38393 and 1.0 mg/kg quinpirole, but not after either of these drugs alone. Thus, behavioral activation and release of neostriatal ascorbate were closely related to the concurrent stimulation of both D1 and D2 dopamine receptors.
引用
收藏
页码：295 / 302
页数：8
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