COCAINE STIMULANT EFFECTS VARY WITH COCAINE LEVELS IN MEDIAL PREFRONTAL CORTEX

被引：4

作者：

CAREY, RJ ^{[1
]}

DAI, HL ^{[1
]}

DAMIANOPOULOS, EN ^{[1
]}

DEPALMA, G ^{[1
]}

机构：

[1] VET ADM MED CTR,RES SERV 151,SYRACUSE,NY 13210

来源：

NEUROREPORT | 1994年 / 5卷 / 17期

关键词：

COCAINE; PSYCHOSTIMULANT; LOCOMOTOR BEHAVIOR; BRAIN PHARMACOKINETICS;

D O I：

10.1097/00001756-199411000-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RATS treated with 10 mg kg(-1) cocaine exhibited hyperlocomotion. Individual variation in the magnitude of this response was not correlated with serum cocaine concentration. Brain cocaine concentration, particularly in the medial prefrontal cortex, was highly correlated with the cocaine-induced locomotor stimulant effect. These findings indicate that variation in the uptake of cocaine into the brain is a critical variable in determining individual variation in its stimulant effects.

引用

页码：2345 / 2348

页数：4

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