ASYMMETRIC-SYNTHESIS OF THE NOVEL ANTIDEPRESSANT ROLIPRAM(R)

被引：26

作者：

MULZER, J

机构：

[1] Institut Für Organische Chemie, Freien Universität, Berlin

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1994年 / 336卷 / 04期

关键词：

D O I：

10.1002/prac.19943360402

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

To illustrate the flexibility of modern asymmetric synthesis six alternative routes are presented for the preparation of the novel antidepressant Rolipram(R). The routes are based on optical resolution, on the concept of ''ex-chiral pool synthesis'' with lactic or tartaric acid as the starting materials, and on the application of chiral auxiliaries. The relative efficiency of the routes is discussed.

引用

页码：287 / 291

页数：5

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