An end in sight? Xrn2 and transcriptional termination by RNA polymerase II

被引：10
|
作者：
Eaton, Joshua D. [1 ]
West, Steven [1 ]
机构：
[1] Univ Exeter, Living Syst Inst, Exeter, Devon, England
来源：
TRANSCRIPTION-AUSTIN | 2018年 / 9卷 / 05期
基金：
英国惠康基金;
关键词：
Xrn2; RNA polymerase II (Pol II); transcriptional termination; 3 ' end processing; cleavage and polyadenylation; RNA degradation;
D O I：
10.1080/21541264.2018.1498708
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Every transcription cycle ends in termination when RNA polymerase dissociates from the DNA. Although conceptually simple, the mechanism has proven somewhat elusive in eukaryotic systems. Gene-editing and high resolution polymerase mapping now offer clarification of important steps preceding transcriptional termination by RNA polymerase II in human cells.
引用
收藏
页码：321 / 326
页数：6
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