AN APPROACH TO THE SYNTHESIS OF (-)-LIPSTATIN BY WITTIG REACTION AND LEWIS ACID-PROMOTED [2+2] CYCLOADDITION

被引：22
|
作者：
PONS, JM [1 ]
POMMIER, A [1 ]
LERPINIERE, J [1 ]
KOCIENSKI, P [1 ]
机构：
[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 14期
关键词：
D O I：
10.1039/p19930001549
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The beta-lactone moiety of (-)-lipstatin 1, a potent inhibitor of pancreatic lipase, is prepared via a Lewis acid-promoted [2 + 2] cycloaddition between hexyltrimethylsilyl ketene 3 and the (Z,Z)-dienic aldehyde 4, obtained from hexanal by two stereoselective Wittig reactions.
引用
收藏
页码：1549 / 1551
页数：3
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