Molecualr Cloning of the capsular antigen F1 of Yersinia pestis in pBAD/gIII plasmid

被引：0

作者：

Jahanian-Najafabadi, A. ^{[1
]}

Soleimani, M. ^{[2
]}

Azadmanesh, K. ^{[3
]}

Mostafavi, E. ^{[4
]}

Majidzadeh-A, K. ^{[2
]}

机构：

[1] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Biotechnol, Esfahan, Iran

[2] AJA Univ Med Sci, Tasinim Biotechnol Res Ctr, Tehran, Iran

[3] Pasteur Inst Iran, Dept Virol, Tehran, Iran

[4] Pasteur Inst Iran, Dept Epidemiol, Tehran, Iran

来源：

RESEARCH IN PHARMACEUTICAL SCIENCES | 2015年 / 10卷 / 01期

关键词：

Yersinia; pestis; Caf1; Capsular antigen F1; pBAD;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Yersinia pestis which is the causative agent of pneumonic plague and distributed in all continents has led to many deaths during the history. Because of its high mortality rate, it must be diagnosed and treated at the earliest time post infection and therefore, rapid diagnostic tests are required. In the present study, we cloned the coding sequence of F1 capsular antigen of the bacteria in the pBAD/gIII plasmid for later expression and purification of the protein to produce poly and monoclonal antibodies against this antigen, and subsequently to develop rapid and efficient diagnostics tools for Y. pestis infections.

引用

页码：84 / 89

页数：6

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