MODELING OF THE LECTIN-HOMOLOGY DOMAINS OF THE HUMAN AND MURINE LOW-AFFINITY FC-EPSILON RECEPTOR (FC-EPSILON-RII/CD23)

被引：0

作者：

PADLAN, EA ^{[1
]}

HELM, BA ^{[1
]}

机构：

[1] UNIV SHEFFIELD, KREBS INST BIOMOLEC RES, DEPT BIOCHEM & MOLEC BIOL, SHEFFIELD S10 2UH, S YORKSHIRE, ENGLAND

来源：

RECEPTOR | 1993年 / 3卷 / 04期

关键词：

HOMOLOGY MODELING; IMMUNOGLOBULIN RECEPTORS; SEQUENCE SIMILARITY; PROTEIN ENGINEERING;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Models of the lectin-homology domains of the human and murine low-affinity receptors for IgE (Fc epsilon RII/CD23) were built on the basis of sequence similarity with rat mannose-binding protein, the structure of which is known. The sites on Fc epsilon RII/CD23 that are possibly involved in the interaction with IgE and with another ligand, CD21/CR2, are proposed. The models may assist the design of protein engineering experiments for the study of the reactivity of these molecules.

引用

页码：325 / 341

页数：17

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