SYNTHESIS OF MURAMYL DIPEPTIDE CONJUGATED WITH ACRIDINE-DERIVATIVES, SHOWING ANTI-HIV-1 AND ANTICANCER ACTIVITY

被引：0
|
作者：
DZIERZBICKA, K
KOLODZIEJCZYK, AM
WYSOCKASKRZELA, B
KOLODZIEJCZYK, AS
机构：
[1] GDANSK TECH UNIV,DEPT DRUG TECHNOL & BIOCHEM,PL-80952 GDANSK,POLAND
[2] UNIV GDANSK,DEPT ORGAN CHEM,PL-80952 GDANSK,POLAND
来源：
POLISH JOURNAL OF CHEMISTRY | 1994年 / 68卷 / 01期
关键词：
ACRIDINE DERIVATIVES; ANTI-HIV ACTIVITY; ANTITUMOR ACTIVITY; PEPTIDES;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of analogues of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) conjugated at position 6 of the carbohydrate residue with some acridine derivatives were synthesized as potential anti-HIV-1 and/or anticancer agents. Preliminary screening data indicate that some of them (4a, 4d and 3e) exhibit anti-HIV-1 activity and some others, including the most active compound 3c, act as antitumor agents.
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页码：37 / 45
页数：9
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