AGE-DEPENDENT VARIATIONS OF LYSOSOMAL ENZYMES IN HUMAN-LIVER

被引：5
|
作者：
MINAMI, R
SATO, S
KUDOH, T
OYANAGI, K
NAKAO, T
机构：
来源：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1979年 / 129卷 / 01期
关键词：
D O I：
10.1620/tjem.129.65
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The specific activities, the Km values, and the elution patterns on DEAE 52 and Sephadex G-150 columns of 6 lysosomal enzymes in human liver during development were studied. The levels of total .beta.-D-glucuronidase and N-acetyl-.beta.-D-glucosaminidase activities in childhood liver were higher than those in fetal liver. The Km values of .beta.-D-glucuronidase and .beta.-D-galactosidase in fetal liver were about 10 times higher than those in childhood liver. The elution patterns on DEAE 52 of .beta.-D-glucuronidase and on Sephadex G-150 of .alpha.-D- and .beta.-D-galactosidases changed with aging. Lysosomal enzymes related to degradation of gangliosides and glycosaminoglycans may change during development.
引用
收藏
页码：65 / 70
页数：6
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