AGE-DEPENDENT VARIATIONS OF LYSOSOMAL ENZYMES IN HUMAN-LIVER

被引：5
|
作者：
MINAMI, R
SATO, S
KUDOH, T
OYANAGI, K
NAKAO, T
机构：
来源：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1979年 / 129卷 / 01期
关键词：
D O I：
10.1620/tjem.129.65
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The specific activities, the Km values, and the elution patterns on DEAE 52 and Sephadex G-150 columns of 6 lysosomal enzymes in human liver during development were studied. The levels of total .beta.-D-glucuronidase and N-acetyl-.beta.-D-glucosaminidase activities in childhood liver were higher than those in fetal liver. The Km values of .beta.-D-glucuronidase and .beta.-D-galactosidase in fetal liver were about 10 times higher than those in childhood liver. The elution patterns on DEAE 52 of .beta.-D-glucuronidase and on Sephadex G-150 of .alpha.-D- and .beta.-D-galactosidases changed with aging. Lysosomal enzymes related to degradation of gangliosides and glycosaminoglycans may change during development.
引用
收藏
页码：65 / 70
页数：6
相关论文
共 50 条
  • [1] AGE-DEPENDENT CHANGES IN ACTIVITY OF LYSOSOMAL ENZYMES IN HUMAN SERUM AND TISSUES
    PLATT, D
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1970, 95 (12) : 634 - &
  • [2] Age-dependent Expression Analysis of Major Drug Metabolizing Enzymes in Human Liver
    Mehrotra, Aanchal
    Boberg, Mikael
    Vrana, Marc
    Gaedig, Andrea
    Pearce, Robin E.
    Leeder, Steven
    Prasad, Bhagwat
    FASEB JOURNAL, 2016, 30
  • [3] PROPERTIES OF HUMAN-LIVER LYSOSOMAL SIALIDASE
    MICHALSKI, JC
    CORFIELD, AP
    SCHAUER, R
    BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1986, 367 (08): : 715 - 722
  • [4] AGE-DEPENDENT CHANGES IN LEVEL OF LYSOSOMAL ENZYMES IN LYMPHATIC ORGANS OF GUINEA PIG
    SZIGETI, M
    ACTA BIOLOGICA ACADEMIAE SCIENTIARUM HUNGARICAE, 1968, 19 (03): : 305 - +
  • [5] AGE-DEPENDENT CHANGE IN ACTIVITIES OF LYSOSOMAL-ENZYMES IN RAT-BRAIN
    NAKAMURA, Y
    TAKEDA, M
    SUZUKI, H
    MORITA, H
    TADA, K
    HARIGUCHI, S
    NISHIMURA, T
    MECHANISMS OF AGEING AND DEVELOPMENT, 1989, 50 (03) : 215 - 225
  • [6] AGE-DEPENDENT KINETIC STUDIES OF CYTOPLASMIC AND LYSOSOMAL ENZYMES OF NORMAL AND D-GALACTOSAMINE INJURED RAT-LIVER
    PLATT, D
    FORSTER, K
    FORSTER, L
    MECHANISMS OF AGEING AND DEVELOPMENT, 1978, 7 (03) : 183 - 188
  • [7] BIOTRANSFORMATION ENZYMES IN HUMAN-LIVER MALIGNANCIES
    ELMOUELHI, M
    KAUFFMAN, FC
    DIDOLKAR, MS
    ELIAS, EG
    GUENGERICH, FP
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1986, 27 : 149 - 149
  • [8] AGE-DEPENDENT VARIATIONS OF THE HUMAN MIGRATING MOTOR COMPLEX (MMC)
    FENTON, TR
    MILLA, PJ
    PEDIATRIC RESEARCH, 1984, 18 (10) : 1061 - 1061
  • [9] AGE-DEPENDENT MODIFICATIONS OF LIPOGENIC ENZYMES
    IRITANI, N
    FUKUDA, H
    FUKUDA, E
    BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 665 (03) : 636 - 639
  • [10] AGE DEPENDENT DETERMINATIONS OF LYSOSOMAL ENZYMES IN LIVER OF SPIRONOLACTONE AND ALDOSTERONE PRETREATED RATS
    PLATT, D
    PAULI, H
    EXPERIMENTAL GERONTOLOGY, 1972, 7 (01) : 1 - +
12345