CYTOTOXICITY OF CYANOBACTERIUM MICROCYSTIS-AERUGINOSA

被引：4
|
作者：
HENNING, K [1 ]
CREMER, J [1 ]
MEYER, H [1 ]
机构：
[1] MED ACAD,FED ARMED FORCES,INST MICROBIOL,MUNICH,GERMANY
来源：
JOURNAL OF VETERINARY MEDICINE SERIES B-ZENTRALBLATT FUR VETERINARMEDIZIN REIHE B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH | 1992年 / 39卷 / 04期
关键词：
D O I：
10.1111/j.1439-0450.1992.tb01174.x
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Cytotoxic effects of crude extracts and fractions of the purification steps towards Microcystin-LR (MCYST-LR) were investigated in vitro. Cytoxicity was evaluated by measure of lactate dehydrogenase liberation of Chang liver cells and by hemolysis. Crude extracts of strain PCC 7806 damaged the cells within a few minutes. In contrast, MCYST-LR did not show any detectable cytotoxic effects. The cytotoxic activity could be related to a heat-labile substance with a molecular weight of about 30,000 Da.
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页码：307 / 310
页数：4
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