RESOLUTION OF TERFENADINE ENANTIOMERS BY BETA-CYCLODEXTRIN CHIRAL STATIONARY PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：13

作者：

WEEMS, H ^{[1
]}

ZAMANI, K ^{[1
]}

机构：

[1] UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DIV CLIN PHARMACOL,BETHESDA,MD 20814

来源：

CHIRALITY | 1992年 / 4卷 / 04期

关键词：

HPLC; CHIRAL STATIONARY PHASE; OPTICAL ISOMERS; ABSOLUTE CONFIGURATION; CIRCULAR DICHROISM; CHIRAL; ENANTIOMERS; TERFENADINE; CYCLODEXTRIN; NORMAL PHASE;

D O I：

10.1002/chir.530040411

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Enantiomers of terfenadine were resolved by high-performance liquid chromatography (HPLC) using a chiral stationary phase (CSP) column packed with beta-cyclodextrin (beta-CD) covalently bound to silica. Separation was achieved in both the reverse phase and normal phase modes. Resolution of enantiomers was confirmed by ultraviolet-visible absorption, circular dichroism, and mass spectral analysis.

引用

页码：268 / 272

页数：5

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