RESOLUTION OF TERFENADINE ENANTIOMERS BY BETA-CYCLODEXTRIN CHIRAL STATIONARY PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：13
|
作者：
WEEMS, H [1 ]
ZAMANI, K [1 ]
机构：
[1] UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DIV CLIN PHARMACOL,BETHESDA,MD 20814
来源：
CHIRALITY | 1992年 / 4卷 / 04期
关键词：
HPLC; CHIRAL STATIONARY PHASE; OPTICAL ISOMERS; ABSOLUTE CONFIGURATION; CIRCULAR DICHROISM; CHIRAL; ENANTIOMERS; TERFENADINE; CYCLODEXTRIN; NORMAL PHASE;
D O I：
10.1002/chir.530040411
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Enantiomers of terfenadine were resolved by high-performance liquid chromatography (HPLC) using a chiral stationary phase (CSP) column packed with beta-cyclodextrin (beta-CD) covalently bound to silica. Separation was achieved in both the reverse phase and normal phase modes. Resolution of enantiomers was confirmed by ultraviolet-visible absorption, circular dichroism, and mass spectral analysis.
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页码：268 / 272
页数：5
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