SYNTHESIS OF FLUORO-DIDEUTERO-METHYL 1,1,1,3,3,3-HEXAFLUORO-2-PROPYL ETHER (DEUTERATED SEVOFLURANE)

被引：7
|
作者：
BAKER, MT
CHIANG, CK
TINKER, JH
机构：
[1] Department of Anesthesia, University of Iowa, Iowa City, Iowa
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1993年 / 33卷 / 09期
关键词：
SEVOFLURANE; DEUTERATION; FLUORINATION;
D O I：
10.1002/jlcr.2580330902
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Sevoflurane was synthesized with deuterium substituents on the fluoromethoxy carbon. This was performed by a two-step reaction process that yielded deuterated sevoflurane of high purity.
引用
收藏
页码：801 / 807
页数：7
相关论文
共 50 条
  • [41] THE ETA-PI-STAR-COTTON EFFECTS OF KETONES IN 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL
    GAWRONSKI, JK
    GAWRONSKA, K
    KOPUT, J
    POLISH JOURNAL OF CHEMISTRY, 1986, 60 (1-3) : 45 - 54
  • [42] Convenient syntheses of 1,1,1,3,3,3-hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers
    Babadzhanova, LA
    Kirij, NV
    Yagupolskii, YL
    Tyrra, W
    Naumann, D
    TETRAHEDRON, 2005, 61 (07) : 1813 - 1819
  • [43] General Hydroamination of Allenamides: Mechanistic Insights with an Acetate Adduct and 1,1,1,3,3,3-Hexafluoro-2-propanol
    Sagar, Kadiyala
    Pradhan, Tapas R.
    Farah, Abdikani Omar
    Wise, Henry R.
    Merja, Bhailal C.
    Srimannarayana, Malempati
    Cheong, Paul Ha-Yeon
    Park, Jin Kyoon
    ORGANIC LETTERS, 2023, 25 (30) : 5574 - 5578
  • [44] Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol
    Motiwala, Hashim F.
    Yin, Qin
    Aube, Jeffrey
    MOLECULES, 2016, 21 (01)
  • [45] Thermodynamics of thermal denaturation of ribonuclease A and cytochrome c in the presence of 1,1,1,3,3,3-hexafluoro-2-propanol
    Kishore, N
    Ranjana
    JOURNAL OF CHEMICAL THERMODYNAMICS, 2001, 33 (10): : 1325 - 1344
  • [46] Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol
    Motiwala, Hashim F.
    Vekariya, Rakesh H.
    Aube, Jeffrey
    ORGANIC LETTERS, 2015, 17 (21) : 5484 - 5487
  • [47] FLUOROALCOHOLS .6. HEATS OF MIXING IN SYSTEM 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL-WATER
    KIVINEN, A
    MURTO, J
    VIITALA, A
    SUOMEN KEMISTILEHTI, 1967, 40 (11): : 298 - &
  • [48] 4-Fluorophenyl 4-{1,1,1,3,3,3-hexafluoro2-[4-(4-fluorobenzoyl)phenyl]-2-propyl}phenyl ketone
    de Barbarin, Cecilia Rodriguez
    Bernes, Sylvain
    Macossay, Javier
    Cassidy, Patrick E.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O3600 - O3601
  • [49] Experimental and Computational Investigations of the Tropospheric Photooxidation Reactions of 1,1,1,3,3,3-Hexafluoro-2-Methyl-2-Propanol Initiated by OH Radicals and Cl Atoms
    Kumar, Avinash
    Gonu, Srinivasulu
    Vijayakumar, S.
    Ramya, C. B.
    Rajakumar, B.
    JOURNAL OF PHYSICAL CHEMISTRY A, 2021, 125 (02): : 523 - 535
  • [50] 1,1,1,3,3,3-hexafluoro-2,2-bis(4-hydroxyphenyl)propane-benzene (2/3)
    Csoregh, Ingeborg
    Toda, Fumio
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O1769 - O1771
12345