SYNTHESIS OF [C-11] SARIN

被引：12
|
作者：
PRENANT, C
CROUZEL, C
机构：
[1] Service Hospitalier Frédéric Joliot, Département de Biologie Commissariat à l'Energie Atomique, Orsay
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1990年 / 28卷 / 06期
关键词：
D O I：
10.1002/jlcr.2580280604
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
[11C]‐acetone, prepared from 11CO2 and methyllithium, was reduced to [11C]‐isopropanol. The latter reacted with methylphosphonic acid difluoride in the presence of diisopropylamine, to yield [11C]‐sarin. 3.4 GBq (100 mCi) of [11C]‐sarin may be obtained from about 55.5 GBq (1.5 Ci) of 11CO2 in 40 minutes. The product purified by HPLC, is obtained with a specific radioactivity ranging from 22.2 to 33.3 GBq (600 to 900 mCi/μmol.). Copyright © 1990 John Wiley & Sons, Ltd.
引用
收藏
页码：645 / 651
页数：7
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