OBESITY, A DISORDER OF NUTRIENT PARTITIONING - THE MONA-LISA HYPOTHESIS

被引:217
|
作者
BRAY, GA
机构
[1] Pennington Biomed Res Center, Department of Medicine, LA State Univ School of Med, Baton Rouge
来源
JOURNAL OF NUTRITION | 1991年 / 121卷 / 08期
关键词
FOOD INTAKE; SYMPATHETIC ACTIVITY; ADRENAL GLUCOCORTICOIDS; HYPOTHALAMUS; GENETICS; OBESITY;
D O I
10.1093/jn/121.8.1146
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The mechanisms underlying different types of obesity have been gradually clarified. Animal models with hypothalamic, genetic or dietary obesity have been examined with a feedback model. Four common final pathways are involved in this model. One of these final common pathways is the sympathetic nervous system. Most Obesities kNown Are Low In Sympathetic Activity states the MONA LISA Hypothesis. A second common pathway is the endocrine system involving adrenal glucocorticosteroids. The third common pathway is hyperphagia. Although not essential for most obesities, hyperphagia may be essential in animals with injury to the hypothalamic paraventricular nucleus. The final pathway is reduced physical activity. The tonic activity of these systems and their response to changes in the diet affect nutrient partitioning between fat and protein. This framework has been used to review genetic obesity, hypothalamic obesity and dietary obesity.
引用
收藏
页码:1146 / 1162
页数:17
相关论文
共 47 条
  • [41] The role of nutrient partitioning and stem cell differentiation in pediatric obesity: a new theory
    Gutin, Bernard
    INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY, 2011, 6 : 7 - 12
  • [42] Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning
    Friedman, Mark I.
    Sorensen, Thorkild I. A.
    Taubes, Gary
    Lund, Jens
    Ludwig, David S.
    OBESITY REVIEWS, 2024, 25 (10)
  • [43] Hyper-sedentary Behavior, Energy Balance, Adipogenic Nutrient Partitioning And The Etiology Of Obesity
    Archer, Edward C.
    Beets, Michael W.
    Hand, Greg A.
    JOURNAL OF GENERAL INTERNAL MEDICINE, 2012, 27 : 268 - 268
  • [44] Hyper-sedentary Behavior, Energy Balance, Adipogenic Nutrient Partitioning And The Etiology Of Obesity
    Archer, Edward C.
    Beets, Michael W.
    Hand, Greg A.
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2011, 43 (05): : 268 - 268
  • [45] Cell-Specific "Competition for Calories" Drives Asymmetric Nutrient-Energy Partitioning, Obesity, and Metabolic Diseases in Human and Non-human Animals
    Archer, Edward
    Pavela, Gregory
    McDonald, Samantha
    Lavie, Carl J.
    Hills, James O.
    FRONTIERS IN PHYSIOLOGY, 2018, 9
  • [46] A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype Hypothesis
    Levitan R.D.
    Masellis M.
    Lam R.W.
    Kaplan A.S.
    Davis C.
    Tharmalingam S.
    Mackenzie B.
    Basile V.S.
    Kennedy J.L.
    Neuropsychopharmacology, 2006, 31 (11) : 2498 - 2503
  • [47] Erratum: A Birth-Season/DRD4 Gene Interaction Predicts Weight Gain and Obesity in Women with Seasonal Affective Disorder: A Seasonal Thrifty Phenotype Hypothesis
    Robert D Levitan
    Mario Masellis
    Raymond W Lam
    Allan S Kaplan
    Caroline Davis
    Subi Tharmalingam
    Bronwyn Mackenzie
    Vincenzo S Basile
    James L Kennedy
    Neuropsychopharmacology, 2006, 31 : 2504 - 2504