PREPARATION OF (6R)-(1R,4R)-6-METHYL-2-(PARA-TOLUENESULFONYL)-5-PHENYLMETHYL-2,5-DIAZABICYCLO[2.2.1]HEPTANES, AND (6S)-(1R,4R)-6-METHYL-2-(PARA-TOLUENESULFONYL)-5-PHENYLMETHYL-2,5-DIAZABICYCLO[2.2.1]HEPTANES, INTERMEDIATES IN A SYNTHESIS OF NEW QUINOLONES

被引：7

作者：

REMUZON, P

BOUZARD, D

DUSSY, C

JACQUET, JP

MASSOUDI, M

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, 77422 Marne-la-Vallee Cedex 2, B.P.62, Lognes

来源：

HETEROCYCLES | 1992年 / 34卷 / 02期

关键词：

D O I：

10.3987/COM-91-5925

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient chiral synthesis of both diastereoisomers (2a) and (2b) was performed using trans-4-hydroxy-L-proline as starting material. These bridged piperazines were used in the preparation of quinolones.

引用

页码：241 / 245

页数：5

共 50 条

[41] (-)-QUINIC ACID IN ORGANIC-SYNTHESIS .1. A FACILE SYNTHESIS OF 2-CROTONYLOXYMETHYL-(4R,5R,6R)-4,5,6-TRIHYDROXYCYCLOHEX-2-ENONE
SHING, TKM
TANG, Y
TETRAHEDRON, 1990, 46 (18) : 6575 - 6584
[42] Stereocontrolled transformation of nitrohexofuranoses into cyclopentylamines via 2-oxabicyclo[2.2.1]heptanes. IV: Synthesis of enantiopure methyl (1S,2R,3R,4R,5S)-5-benzyloxycarbonylamino-2,3-isopropylidenedioxy-4-methoxycyclopentanecarboxylate
Fernandez, Fernando
Estevez, Amalia M.
Estevez, Juan C.
Estevez, Ramon J.
TETRAHEDRON-ASYMMETRY, 2009, 20 (6-8) : 892 - 896
[43] Synthesis of (4R,6S,7R)-7-hydroxy-4,6-dimethyl-3-nonanone and (3R,5S,6R)-6-hydroxy-3,5-dimethyl-2-octanone
Sabitha, Gowravaram
Srinivas, Chitti
Maruthi, Chittapragada
Yadav, Jhillu Singh
TETRAHEDRON-ASYMMETRY, 2011, 22 (24) : 2071 - 2079
[44] Synthesis of (-)-(1R,2R,4R,6S)-1,6-Epoxy-4-benzyloxyc yclohexan$ MIN@2-ol, a key precursor to inositol monophosphatase inhibitors, from (-)-quinic acid
Tetrahedron Lett, 1 (111):
[45] METHYL REL-(1R,2R,3S,4S,5S,6S,7R,8R)-1,4-5,8-DIEPOXY-1,2,3,4,5,6,7,8-OCTAHYDROANTHRACENE-2,3,6,7-TETRACARBOXYLATE
KOHNKE, FH
STODDART, JF
SLAWIN, AMZ
WILLIAMS, DJ
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1988, 44 : 740 - 742
[46] (3aS,5aR,6R,8aR)-3a-hydroxy-5a-methyl-6-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-3a,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[e]benzofuran-2-one
Wang, Wen-Liang
Tao, Hong-Wen
Sun, Wei
Gu, Qian-Qun
Zhu, Wei-Ming
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O4196 - U2258
[47] A 1:1 cocrystal of (1R,3S,4S,6R)-1,2,3,4,5,6-hexabromo-1,2,3,4,5,6-hexahydropentalene and (1R,2R,4S,5S)-1,2,3,4,5,6-hexabromo-1,2,4,5-tetrahydropentalene
Hokelek, Tuncer
Gunbas, Duygu D.
Algi, Fatih
Balci, Metin
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O2466 - O2468
[48] ([(1R,2S,3R,6R)-2-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)-6-(2-FURYL)-3-METHYL-4-OXOCYCLOHEXYL](METHOXY)METHYLENE)-PENTACARBONYLTUNGSTEN(0)
GARCIAGRANDO, S
PEREZCARRENO, E
PANEQUEQUEVEDO, AA
BARLUENGA, S
MARTIN, A
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1994, 50 : 1430 - 1432
[49] ASYMMETRIC REACTIONS .60. ABSOLUTE-CONFIGURATION OF (1R,2S,4R,6S,7R)-(+)-3-OXOTRICYCLO[2,2,1,02,6]HEPTANE-7-CARBOXYLIC ACID
CERVINKA, O
HABARTOVA, E
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1983, 48 (12) : 3565 - 3566
[50] (1R, 4R, 6S, 7S)-5,5-Dichloro-1,4,8,8-tetra-methyltricyclo[5.4.1(1,7).0(4,6)]dodecan-12-one
Benharref, Ahmed
El Karroumi, Jamal
Daran, Jean-Claude
Berraho, Moha
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O1703 - +

← 1 2 3 4 5 →