TREATMENT WITH ASSOCIATED SODIUM-BUTYRATE AND IL-2 AGAINST RAT PERITONEAL CARCINOMATOSIS INDUCED BY A COLON-CARCINOMA CELL-LINE

被引：0
|
作者：
PERRIN, P
BURG, C
VAVASSEUR, F
GALMICHE, JP
BORNET, F
MEFLAH, K
机构：
[1] DEPT NUTR & SANTE,GRP ERIDANIA BEGHIN SAY,F-75008 PARIS,FRANCE
[2] CHU NORD,FONCT DIGEST & NUTR LAB,F-44035 NANTES 01,FRANCE
来源：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1993年 / 316卷 / 06期
关键词：
COLON CANCER; IMMUNOTHERAPY; INTERLEUKIN-2; SODIUM BUTYRATE; PERITONEAL CARCINOMATOSIS;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Two therapeutic assays associating sodium butyrate (NaB) and interleukin-2 (IL-2) were applied on rats after intraperitoneal (i.p.) injection of colon carcinoma cells. The first assay began at day 1 after cell injection, and the second one at day 10 after injection, i. e. when carcinomatosis was established. IL-2 was given i.p. three times per day and NaB one time per day, for five and seven days respectively. The survival median of IL-2 treated rats significantly increased versus those of untreated ones, and was much higher with NaB in supplement. Moreover, using this associative treatment, we observed some cases of complete curacy, even in rats bearing established carcinomatosis.
引用
收藏
页码：611 / 614
页数：4
相关论文
共 50 条
  • [41] THE EFFECTS OF 5-FLUOROURACIL AND METHOTREXATE ON THE DEOXYURIDINE SUPPRESSION TEST IN THE HUMAN COLON-CARCINOMA CELL-LINE CACO-2
    CHOI, SW
    SHANE, B
    SELHUB, J
    FASEB JOURNAL, 1994, 8 (04): : A96 - A96
  • [42] TRANSFORMING GROWTH-FACTOR-BETA-2 IS AN AUTOCRINE GROWTH INHIBITORY FACTOR FOR THE MOSER HUMAN COLON-CARCINOMA CELL-LINE
    LEVINE, AE
    LEWIS, LR
    CANCER LETTERS, 1993, 68 (01) : 33 - 41
  • [43] CONCOMITANT INCREASES IN GALECTIN-1 AND ITS GLYCOCONJUGATE LIGANDS (CARCINOEMBRYONIC ANTIGEN, LAMP-1, AND LAMP-2) IN CULTURED HUMAN COLON-CARCINOMA CELLS BY SODIUM-BUTYRATE
    OHANNESIAN, DW
    LOTAN, D
    LOTAN, R
    CANCER RESEARCH, 1994, 54 (22) : 5992 - 6000
  • [44] CO-AMPLIFICATION AND OVER-EXPRESSION OF 2 MDR GENES IN A MULTIDRUG-RESISTANT HUMAN COLON-CARCINOMA CELL-LINE
    CHAO, CCK
    MA, CM
    LINCHAO, S
    FEBS LETTERS, 1991, 291 (02): : 214 - 218
  • [45] CORRELATION BETWEEN ALPHA 2,6-LINKED SIALIC-ACID EXPRESSION AND TUMORIGENICITY IN A HUMAN COLON-CARCINOMA CELL-LINE
    MURAYAMA, T
    ZUBER, C
    ROTH, J
    LABORATORY INVESTIGATION, 1993, 68 (01) : A49 - A49
  • [46] THE COLON-CARCINOMA CELL-LINE CACO-2 CONTAINS AN H+/K+-ATPASE THAT CONTRIBUTES TO INTRACELLULAR PH REGULATION
    ABRAHAMSE, SL
    BINDELS, RJM
    VANOS, CH
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1992, 421 (06): : 591 - 597
  • [47] CELLULAR AND MOLECULAR MECHANISMS OF IFN-GAMMA PRODUCTION INDUCED BY IL-2 AND IL-12 IN A HUMAN NK CELL-LINE
    YE, JP
    ORTALDO, JR
    CONLON, K
    WINKLERPICKETT, R
    YOUNG, HA
    JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 58 (02) : 225 - 233
  • [48] BIOSYNTHESIS AND TRANSPORT OF LYSOSOMAL ALPHA-GLUCOSIDASE IN THE HUMAN COLON-CARCINOMA CELL-LINE CACO-2 - SECRETION FROM THE APICAL SURFACE
    KLUMPERMAN, J
    FRANSEN, JAM
    BOEKESTIJN, TC
    ELFERINK, RPJO
    MATTER, K
    HAURI, HP
    TAGER, JM
    GINSEL, LA
    JOURNAL OF CELL SCIENCE, 1991, 100 : 339 - 347
  • [49] EXPRESSION OF IL-7-RECEPTOR CHAINS TRANSCRIPTS IN HUMAN INTESTINAL LAMINA PROPRIA MONONUCLEAR-CELLS (LPMC) AND IN THE CACO-2 HUMAN COLON-CARCINOMA CELL-LINE
    MARASCO, R
    MARASCO, O
    MORRONE, G
    MONTELEONE, G
    LUZZA, F
    VENUTA, S
    PALLONE, F
    GASTROENTEROLOGY, 1995, 108 (04) : A870 - A870
  • [50] LAMININ EXPRESSION BY 2 CLONES ISOLATED FROM THE COLON-CARCINOMA CELL-LINE LOVO THAT DIFFER IN METASTATIC POTENTIAL AND BASEMENT-MEMBRANE ORGANIZATION
    REMY, L
    LISSITZKY, JC
    DAEMI, N
    JACQUIER, MF
    BAILLY, M
    MARTIN, PM
    BIGNON, C
    DORE, JF
    INTERNATIONAL JOURNAL OF CANCER, 1992, 51 (02) : 204 - 212
12345