SENEGALENE, A NEW MONOTETRA HYDROFURANIC OLEFINIC ACETOGENIN FROM ANNONA-SENEGALENSIS SEEDS

被引：16
|
作者：
SAHPAZ, S
LAURENS, A
HOCQUEMILLER, R
CAVE, A
CORTES, D
机构：
[1] UNIV PARIS 11, FAC PHARM, CNRS, PHARMACOGNOISE LAB, F-92290 CHATENAY MALABRY, FRANCE
[2] UNIV VALENCIA, FAC FARM, DEPT FARMACOL, E-46100 BURJASSOT, SPAIN
[3] UNIV ROUEN, FAC MED & PHARM, PHARMACOGNOISE LAB, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
来源：
CANADIAN JOURNAL OF CHEMISTRY | 1994年 / 72卷 / 06期
关键词：
D O I：
10.1139/v94-190
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Using activity-directed fractionation, the chromatography of the bioactive methanol extract of Annona senegalensis seeds led to isolation of a new mono-tetrahydrofuranic gamma-lactone acetogenin characterized by the presence of a double bond on the alkyl chain, senegalene 1. Its structure was elucidated on the basis of spectroscopic (2D-NMR and MS) and chemical methods. Four known acetogenins have been also isolated: molvizarin 2, asimicin 3, rolliniastatin-2 4, and squamocin 5. Comparative structure-activity relationships were studied using senegalene 1 and its derivatives in KB and VERO cell lines in in vitro tests.
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收藏
页码：1533 / 1536
页数：4
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