FROM CORONARY-ARTERY DISEASE TO HEART-FAILURE - ROLE OF THE HIBERNATING MYOCARDIUM

Hibernating myocardium is defined as persistently impaired myocardial and left ventricular (LV) function at rest resulting from reduced myocardial blood flow. It may occur in unstable angina and chronic stable angina, acute myocardial infarction, and LV dysfunction and congestive heart failure. Recovery of the hibernating myocardium has clearly been shown to occur with the establishment of successful revascularization either by coronary bypass surgery or by percutaneous transluminal coronary angioplasty. It may be possible to show recovery of the viable myocardium by reducing myocardial oxygen demand and/or by increasing coronary blood flow with pharmaceutical agents.