ORTHO-HYDROXYPHENYLACETALDEHYDE - A MAJOR NOVEL METABOLITE OF COUMARIN FORMED BY RAT, GERBIL AND HUMAN LIVER-MICROSOMES

被引：32
|
作者：
FENTEM, JH [1 ]
FRY, JR [1 ]
WHITING, DA [1 ]
机构：
[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 01期
关键词：
D O I：
10.1016/0006-291X(91)91354-F
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A major novel coumarin metabolite was isolated from rat hepatic microsomal incubations by high-performance liquid chromatography. In the presence of a rat liver cytosolic fraction and NADH it was rapidly metabolized to o-hydroxyphenylethanol. The metabolite co-chromatographed with an authentic sample of o-hydroxyphenylacetaldehyde and its identity was confirmed by mass spectral analysis. The formation of o-hydroxyphenyl acetaldehyde from coumarin was NADPH-dependent. It was the major metabolite formed by rat, gerbil and human liver microsomes at a coumarin concentration of 1mM. © 1991.
引用
收藏
页码：197 / 203
页数：7
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