A POSITIVE REGULATOR OF THE RIBOSOMAL-PROTEIN GENE, BETA-FACTOR, BELONGS TO THE ETS ONCOPROTEIN FAMILY

被引：22
|
作者：
YOGANATHAN, T
BHAT, NK
SELLS, BH
机构：
[1] UNIV GUELPH,COLL BIOL SCI,DEPT MOLEC BIOL & GENET,GUELPH N1G 2W1,ONTARIO,CANADA
[2] NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,MOLEC ONCOL LAB,FREDERICK,MD 21702
来源：
BIOCHEMICAL JOURNAL | 1992年 / 287卷
关键词：
D O I：
10.1042/bj2870349
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The beta factor, which interacts with the rpL32 promoter, binds to the sequence 5'-GAGCCGGAAGTG and trans-activates this gene. Comparison of the DNA sequences bound by the beta factor with those bound by other known DNA-binding proteins revealed that the ETS proteins interact with similar DNA sequences. Consequently we have examined the relationship of the beta factor to the several ETS proteins so far reported. Antibody and oligonucleotide competition experiments, performed by using electrophoretic shift analysis, revealed that the beta factor contains ETS epitopes and that it is immunologically related to both of the GA-binding proteins (GABPs), implying that the beta factor may consist of two separate protein subunits.
引用
收藏
页码：349 / 353
页数：5
相关论文
共 32 条
  • [21] The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells
    Reichman, TW
    Muñiz, LC
    Mathews, MB
    MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (01) : 343 - 356
  • [22] HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene
    Aiello, Aurora
    Pandini, Giuseppe
    Sarfstein, Rive
    Werner, Haim
    Manfioletti, Guidalberto
    Vigneri, Riccardo
    Belfiore, Antonino
    EUROPEAN JOURNAL OF CANCER, 2010, 46 (10) : 1919 - 1926
  • [23] Ribosomal RNA Gene Transcription Mediated by the Master Genome Regulator Protein CCCTC-binding Factor (CTCF) Is Negatively Regulated by the Condensin Complex
    Huang, Kaimeng
    Jia, Jinping
    Wu, Changwei
    Yao, Mingze
    Li, Min
    Jin, Jingji
    Jiang, Cizhong
    Cai, Yong
    Pei, Duanqing
    Pan, Guangjin
    Yao, Hongjie
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (36) : 26067 - 26077
  • [24] A TRANSCRIPT FROM A DROSOPHILA PATTERN GENE PREDICTS A PROTEIN HOMOLOGOUS TO THE TRANSFORMING GROWTH-FACTOR-BETA FAMILY
    PADGETT, RW
    STJOHNSTON, RD
    GELBART, WM
    NATURE, 1987, 325 (6099) : 81 - 84
  • [25] CHARACTERIZATION OF THE MULTIGENE FAMILY ENCODING THE MOUSE S16 RIBOSOMAL-PROTEIN - STRATEGY FOR DISTINGUISHING AN EXPRESSED GENE FROM ITS PROCESSED PSEUDOGENE COUNTERPARTS BY AN ANALYSIS OF TOTAL GENOMIC DNA
    WAGNER, M
    PERRY, RP
    MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (12) : 3560 - 3576
  • [26] NF-BETA-A, A FACTOR REQUIRED FOR MAXIMAL INTERLEUKIN-1-BETA GENE-EXPRESSION IS IDENTICAL TO THE ETS FAMILY MEMBER PU.1 - EVIDENCE FOR STRUCTURAL ALTERATION FOLLOWING LPS ACTIVATION
    BURAS, JA
    REENSTRA, WR
    FENTON, MJ
    MOLECULAR IMMUNOLOGY, 1995, 32 (08) : 541 - &
  • [27] MOLECULAR CHARACTERIZATION OF THE MOUSE RIBOSOMAL-PROTEIN S24 MULTIGENE FAMILY - A UNIQUELY EXPRESSED INTRON-CONTAINING GENE WITH CELL-SPECIFIC EXPRESSION OF 3 ALTERNATIVELY SPLICED MESSENGER-RNAS
    XU, L
    HE, GP
    LI, A
    RO, HS
    NUCLEIC ACIDS RESEARCH, 1994, 22 (04) : 646 - 655
  • [28] ASH1L (a histone methyltransferase protein) is a novel candidate globin gene regulator revealed by genetic study of an English family with beta-thalassaemia unlinked to the beta-globin locus
    Breton, Amandine
    Theodorou, Andria
    Aktuna, Suleyman
    Sonzogni, Laura
    Darling, David
    Chan, Lucas
    Menzel, Stephan
    van der Spek, Peter J.
    Swagemakers, Sigrid M. A.
    Grosveld, Frank
    Philipsen, Sjaak
    Thein, Swee Lay
    BRITISH JOURNAL OF HAEMATOLOGY, 2016, 175 (03) : 525 - 530
  • [29] SEQUENCE-ANALYSIS OF A 30 KB DNA SEGMENT FROM YEAST CHROMOSOME-XIV CARRYING A RIBOSOMAL-PROTEIN GENE-CLUSTER, THE GENES ENCODING A PLASMA-MEMBRANE PROTEIN AND A SUBUNIT OF REPLICATION FACTOR-C, AND A NOVEL PUTATIVE SERINE THREONINE PROTEIN-KINASE GENE
    MAURER, KCT
    URBANUS, JHM
    PLANTA, RJ
    YEAST, 1995, 11 (13) : 1303 - 1310
  • [30] Tumor Necrosis Factor [alpha] is a negative regulator of protein kinase C[beta]II gene expression, Akt2 and SR protein dephosphorylation in vascular smooth muscle cells.
    Cooper, DR
    Watson, JE
    Chalfant, CE
    Chappell, DS
    Patel, NA
    Mancu, D
    Mebert, K
    Cheng, J
    FASEB JOURNAL, 2002, 16 (05): : A917 - A917
1234