SEQUENCES OF DNA FRAGMENTS CONTACTING THE NUCLEAR LAMINA INVIVO

被引：18

作者：

CHRISTOVA, R ^{[1
]}

BACH, I ^{[1
]}

GALCHEVAGARGOVA, Z ^{[1
]}

机构：

[1] PASTEUR INST, DEPT BIOTECHNOL, F-75724 PARIS 15, FRANCE

来源：

DNA AND CELL BIOLOGY | 1992年 / 11卷 / 08期

关键词：

D O I：

10.1089/dna.1992.11.627

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To study the DNA sequences contacting the nuclear lamina (NL) in vivo, Ehrlich ascites tumor cells were UV-irradiated. The NL was purified, and the DNA fragments covalently linked to the lamina proteins in vivo were cloned and sequenced. Although heterogeneous in length and composition, the sequences displayed homology to the introns and/or flanking regions of different genes, suggesting that functionally distinct regions are organized in a topologically defined manner at the nuclear periphery.

引用

页码：627 / 636

页数：10

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