CIRCULATORY EFFECTS OF ENDOTHELIN IN NEWBORN PIGLETS

被引:37
|
作者
BRADLEY, LM
CZAJA, JF
GOLDSTEIN, RE
机构
[1] CHILDRENS HOSP, NATL MED CTR, DEPT ANESTHESIOL CRIT CARE MED, WASHINGTON, DC 20010 USA
[2] GEORGE WASHINGTON UNIV, SCH MED, WASHINGTON, DC 20052 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1990年 / 259卷 / 05期
关键词
PULMONARY VASODILATION; SYSTEMIC VASOCONSTRICTION; CORONARY BLOOD FLOW;
D O I
10.1152/ajpheart.1990.259.5.H1613
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Endothelin, a recently described endothelial cell-derived peptide, produces pulmonary and coronary vasoconstriction in mature animals. We investigated the acute hemodynamic effects of porcine endothelin in 14 anesthetized open-chest newborn piglets during normoxia (Pa(o)2 = 102 +/- 5 mmHg) and hypoxia (fractional inspired O2 concentration = 0.12 x 15 min, Pa(o)2 = 31 +/- 1 mmHg). Six of these animals were pretreated with indomethacin, a cyclooxygenase inhibitor. Low-dose (100 pmol/kg) intravenous bolus injection of endothelin decreased pulmonary vascular resistance index (PVRI) (42 +/- 6 to 16 +/- 4 mmHg.1(-1).min.kg, P < 0.01) and increased coronary blood flow (CBF) (17 +/- 2%, P < 0.01); cardiac index (CI) and coronary vascular resistance were unaffected. The pulmonary and coronary responses to endothelin were preserved during hypoxia: PVRI fell (160 +/- 22 to 83 +/- 13 mmHg.1(-1).min.kg, P < 0.05) and CBF rose (35 +/- 11%, P < 0.05). Low-dose endothelin moderately increased mean arterial pressure (61 +/- 3 to 75 +/- 6 mmHg, P < 0.05) and systemic vascular resistance index (SVRI) (375 +/- 23 to 491 +/- 41 mmHg.1(-1).min.kg, P < 0.01). High-dose (1,000 pmol/kg) endothelin mildly decreased PVRI (51 +/- 7 to 35 +/- 12, NS), moderately increased SVRI (375 +/- 45 to 594 +/- 95 mmHg.1(-1).min.kg, P < 0.05), and markedly diminished CBF (-54 +/- 6%, P < 0.01). Left ventricular end-diastolic pressure rose (9 +/- 1 to 17 +/- 3 mmHg, P < 0.05) and shortening fraction fell (15.9 +/- 1.4 to 11.1 +/- 2.0%, P < 0.05) in response to high-dose endothelin. CI did not change. Pretreatment with indomethacin did not significantly alter either the pulmonary or coronary vascular responses to low-dose endothelin but completely prevented high-dose endothelin-induced coronary vasoconstriction and left ventricular dysfunction. The results indicate that cyclooxygenase products are unlikely to exclusively mediate endothelin-induced vasodilation but may play a role in endothelin-induced coronary vasoconstriction in newborn piglets.
引用
收藏
页码:H1613 / H1617
页数:5
相关论文
共 50 条
  • [31] Pulmonary Hemodynamics in Newborn Piglets during Hypoxemia and Reoxygenation: Blocking of the Endothelin-1 Receptors
    Sverre Medbø
    Per Arne Tølløfsrud
    Ola Didrik Saugstad
    Pediatric Research, 1999, 46 : 514 - 514
  • [32] CIRCULATORY EFFECTS OF PLATELET-ACTIVATING-FACTOR IN THE NEWBORN
    BRADLEY, LM
    GOLDSTEIN, RE
    FEUERSTEIN, GZ
    CZAJA, JF
    CIRCULATION, 1987, 76 (04) : 25 - 25
  • [33] Circulatory Effects of Inhaled Iloprost in the Newborn Preterm Lamb
    Tommi Noponen
    Anders Nordh
    Ansgar Berg
    David Ley
    Stefan R Hansson
    Erkki Pesonen
    Vineta Fellman
    Pediatric Research, 2009, 66 : 416 - 422
  • [34] CIRCULATORY EFFECTS OF HEMATOCRIT VARIATIONS IN NORMOVOLEMIC NEWBORN LAMBS
    FOURON, JC
    HEBERT, F
    JOURNAL OF PEDIATRICS, 1973, 82 (06): : 995 - 1003
  • [35] Circulatory Effects of Inhaled Iloprost in the Newborn Preterm Lamb
    Noponen, Tommi
    Nordh, Anders
    Berg, Ansgar
    Ley, David
    Hansson, Stefan R.
    Pesonen, Erkki
    Fellman, Vineta
    PEDIATRIC RESEARCH, 2009, 66 (04) : 416 - 422
  • [36] EFFECTS OF ENDOTHELIN ON RENAL-FUNCTION IN NEWBORN RABBITS
    SEMAMA, DS
    THONNEY, M
    GUIGNARD, JP
    GOUYON, JB
    PEDIATRIC RESEARCH, 1993, 34 (02) : 120 - 123
  • [37] RENAL CIRCULATORY EFFECTS OF ADRENERGIC STIMULI IN ANESTHETIZED PIGLETS AND MATURE SWINE
    BUCKLEY, NM
    BRAZEAU, P
    GOOTMAN, PM
    FRASIER, ID
    AMERICAN JOURNAL OF PHYSIOLOGY, 1979, 237 (06): : H690 - H695
  • [38] EARLY RESPONSE OF INFLAMMATORY PROTEINS IN THE STRIATUM AND HIPPOCAMPUS OF NEWBORN PIGLETS FOLLOWING CARDIOPULMONARY BYPASS AND CIRCULATORY ARREST
    Pastuszko, P.
    Schears, G. J.
    Kubin, J.
    Greeley, W. J.
    Wilson, D. F.
    Pastuszko, A.
    PEDIATRIC RESEARCH, 2011, 70 : 199 - 199
  • [39] THE HEMODYNAMIC EFFECTS OF PROLONGED ALKALOSIS IN ANESTHETIZED NEWBORN PIGLETS † 926
    Khaldon Jundi
    Keith J Barrington
    Neil N Finer
    Pediatric Research, 1997, 41 (Suppl 4) : 157 - 157
  • [40] CARDIOVASCULAR EFFECTS OF HYPOXIA/HYPERCARBIA AND TENSION PNEUMOTHORAX IN NEWBORN PIGLETS
    BRANN, BS
    MAYFIELD, SR
    GOLDSTEIN, M
    OH, W
    STONESTREET, BS
    CRITICAL CARE MEDICINE, 1994, 22 (09) : 1453 - 1460