CHROMATOGRAPHIC AND MASS-SPECTROMETRIC METHODS FOR DETERMINATION OF LYSERGIC-ACID DIETHYLAMIDE (LSD) AND METABOLITES IN BODY-FLUIDS

被引：38
|
作者：
NELSON, CC [1 ]
FOLTZ, RL [1 ]
机构：
[1] NW TOXICOL INC,SALT LAKE CITY,UT 84124
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 580卷 / 1-2期
关键词：
D O I：
10.1016/0378-4347(92)80530-4
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Continued illicit use of the potent psychedelic drug lysergic acid diethylamide (LSD) has stimulated efforts to develop effective analytical methods for detection of the drug and its metabolites in body fluids from suspected LSD users. Recently reported methods based on gas and liquid chromatography, combined with single- and multiple-stage mass spectral analysis, now permit accurate detection and quantitation of LSD at sub-nanogram/milliliter concentrations.
引用
收藏
页码：97 / 109
页数：13
相关论文
共 50 条
  • [21] GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC DETERMINATION OF OXOLINIC, NALIDIXIC, AND PIROMIDIC ACID IN FISH
    TAKATSUKI, K
    JOURNAL OF AOAC INTERNATIONAL, 1992, 75 (06) : 982 - 987
  • [22] GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC DETERMINATION OF AMITRIPTYLINE AND ITS MAJOR METABOLITES IN HUMAN-SERUM
    ISHIDA, R
    OZAKI, T
    UCHIDA, H
    IRIKURA, T
    JOURNAL OF CHROMATOGRAPHY, 1984, 305 (01): : 73 - 82
  • [23] Determination of Lysergic Acid Diethylamide and 2-Oxo-3-Hydroxy-LSD in Blood: Validation and Comparison of Two Liquid Chromatography-Tandem Mass Spectrometry Methods
    Dimitrova, Alexandra
    Di Milia, Maria Grazia
    Rensi, Regina
    Grassi, Simone
    Gualco, Barbara
    Vaiano, Fabio
    SEPARATIONS, 2023, 10 (09)
  • [24] GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC METHOD FOR THE DETERMINATION OF FLURAZEPAM AND ITS MAJOR METABOLITES IN MOUSE AND RAT PLASMA
    SONG, DM
    ZHANG, SD
    KOHLHOF, K
    JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 658 (01): : 142 - 148
  • [25] DETERMINATION OF METOCLOPRAMIDE AND 2 OF ITS METABOLITES USING A SENSITIVE AND SELECTIVE GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC ASSAY
    RIGGS, KW
    SZEITZ, A
    RURAK, DW
    MUTLIB, AE
    ABBOTT, FS
    AXELSON, JE
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1994, 660 (02): : 315 - 325
  • [26] Liquid chromatographic-mass spectrometric determination of cyclooxygenase metabolites of arachidonic acid in cultured cells
    Nithipatikom, K
    Laabs, ND
    Isbell, MA
    Campbell, WB
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 785 (01): : 135 - 145
  • [27] Chromatographic-mass spectrometric methods for the quantification of L-arginine and its methylated metabolites in biological fluids
    Martens-Lobenhoffer, Jens
    Bode-Boeger, Stefanie M.
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 851 (1-2): : 30 - 41
  • [28] GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC DETERMINATION OF AROMATIZATION OF CYCLOHEXANECARBOXYLIC ACID IN GUINEA-PIG LIVER
    SVARDAL, A
    SCHELINE, R
    JOURNAL OF CHROMATOGRAPHY, 1982, 233 (DEC): : 301 - 306
  • [29] GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC DETERMINATION OF OXOLINIC ACID IN FISH USING SELECTED ION MONITORING
    TAKATSUKI, K
    JOURNAL OF CHROMATOGRAPHY, 1991, 538 (02): : 259 - 267
  • [30] Alternative Method for Forensic Determination of Lysergic Acid Diethylamide and Related Compounds in Body Fluids by Liquid–Liquid Extraction and HPLC with Fluorescence Detection
    J. Pietsch
    K. Schulz
    B. Körner
    H. Trauer
    J. Dreßler
    M. Gey
    Chromatographia, 2004, 60 : 89 - 92
12345