Crystallographic phasing and refinement of macromolecules

被引：22
|
作者：
Brunger, Axel T. [1 ,2 ]
机构：
[1] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06511 USA
[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06511 USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1991年 / 1卷 / 06期
关键词：
D O I：
10.1016/0959-440X(91)90100-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent developments in crystallographic phasing and refinement are discussed with particular emphasis on ab initio phasing, molecular replacement, the efficiency of crystallographic refinement, thermal motion, disorder of macromolecules, and bulk solvent. The past year has seen a number of developments in these areas which were made possible by the availability of increased computing power and the application of novel mathematical techniques.
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页码：1016 / 1022
页数：7
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