PRODUCTION OF INTERLEUKIN-8 BY CULTURED SYNOVIAL-CELLS IN RESPONSE TO INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR

被引：0
|
作者：
HIROTA, K
AKAHOSHI, T
ENDO, H
KONDO, H
KASHIWAZAKI, S
机构：
[1] KITASATO UNIV,SCH MED,DEPT INTERNAL MED,1-15-1 KITASATO,SAGAMIHARA,KANAGAWA 228,JAPAN
[2] TOKYO WOMENS MED COLL,INST RHEUMATOL,SHINJUKU KU,TOKYO 162,JAPAN
来源：
RHEUMATOLOGY INTERNATIONAL | 1992年 / 12卷 / 01期
关键词：
INTERLEUKIN-8; SYNOVIAL CELLS; RHEUMATOID ARTHRITIS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Both interleukin 1-alpha (IL-1-alpha) and tumor necrosis factor-alpha (TNF-alpha) stimulated the production of interleukin 8 (IL-8) by synovial cells in time and dose dependent manners. Enhanced chemotactic activity of polymorphonuclear cells (PMN) in culture supernatants of synovial cells was neutralized with anti-IL-8 antibody, thus showing synovial cells to be capable of secreting IL-8 which may contribute to PMN accumulation in rheumatoid inflamed joints.
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页码：13 / 16
页数：4
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