PREDOMINANT EXPANSION OF V-GAMMA-9/V-DELTA-2 T-CELLS IN A TULAREMIA PATIENT

被引：69
|
作者：
SUMIDA, T
MAEDA, T
TAKAHASHI, H
YOSHIDA, S
YONAHA, F
SAKAMOTO, A
TOMIOKA, H
KOIKE, T
YOSHIDA, S
机构：
[1] ASAHI GEN HOSP, DEPT INTERNAL MED, CHIBA, JAPAN
[2] TOHO UNIV, SCH MED, DEPT INTERNAL MED, FUNABASHI, CHIBA 274, JAPAN
来源：
INFECTION AND IMMUNITY | 1992年 / 60卷 / 06期
关键词：
D O I：
10.1128/IAI.60.6.2554-2558.1992
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We describe a 58-year-old man with tularemia and expanding (gamma)delta T cells in his peripheral blood lymphocytes (PBL) (32.7% of total PBL). In the present work, we analyzed the T-cell receptor V(gamma)/V-delta repertoire of these cells by making use of the polymerase chain reaction and flow cytometry and found that they were mostly CD4- CD8- CD3+ V(gamma)9/V-delta-2+. The sequence analysis of 16 cDNA clones encoding the V(gamma)9-J region revealed that the V(gamma)9-Jp combination was strikingly overrepresented but that the junctional (N) region was heterogeneous. This suggested that the (gamma)delta T cells in PBL from a patient with tularemia were polyclonally expanded.
引用
收藏
页码：2554 / 2558
页数：5
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