CARBOXYL-TERMINAL HEPARIN-BINDING FRAGMENTS OF PLATELET FACTOR-IV RETAIN THE BLOCKING EFFECT ON THE RECEPTOR-BINDING OF BASIC FIBROBLAST GROWTH-FACTOR

被引：20

作者：

SATO, Y

WAKI, M

OHNO, M

KUWANO, M

SAKATA, T

机构：

[1] OITA MED UNIV,DEPT BIOCHEM,HASAMA MACHI,OITA 87955,JAPAN

[2] KYUSHU UNIV,FAC SCI,DEPT CHEM,BIOCHEM LAB,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1993年 / 84卷 / 05期

关键词：

PLATELET FACTOR-IV; HEPARIN-BINDING DOMAIN; BASIC FIBROBLAST GROWTH FACTOR; RECEPTOR BINDING;

D O I：

10.1111/j.1349-7006.1993.tb00163.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Platelet factor 4 (PF-4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl-terminal fragments, which represent the heparin-binding region of the PF-4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF. Synthetic peptides inhibited the receptor binding of bFGF. Furthermore, they inhibited the migration and tube formation of bovine capillary endothelial cells in culture (these phenomena are dependent on endogenous bFGF).

引用

页码：485 / 488

页数：4

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