Localization of the human homolog of the yeast cell division control 27 gene (CDC27) proximal to ITGB3 on human chromosome 17q21.3

被引：2

作者：

Ho, PP

Couch, FJ

Brody, LC

Abel, KJ

Boehnke, M

Shearon, TH

Chandrasekharappa, SC

Collins, FS

Weber, BL

机构：

[1] UNIV PENN,DEPT INTERNAL MED,PHILADELPHIA,PA 19104

[2] NATL CTR HUMAN GENOME RES,NIH,LAB GENE TRANSFER,BETHESDA,MD 20892

[3] MICROBIOL UNIT,DEPT HUMAN GENET,ANN ARBOR,MI 48109

[4] MICROBIOL UNIT,DEPT BIOSTAT,ANN ARBOR,MI 48109

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1995年 / 21卷 / 05期

关键词：

D O I：

10.1007/BF02257470

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human homolog of the Saccharomyces cerevisiae cell division control 27 gene (CDC27) was mapped to human chromosome 17q12-q21 using a panel of human/rodent somatic cell hybrids and localized distal to the breast cancer susceptibility gene, BRCA1, using a panel of radiation hybrids. The radiation hybrid panel indicates that the most likely position of human CDC27 on human chromosome 17 is between the marker DI7S409 and the beta 3 subunit of integrin (ITGB3). Further confirmation of this localization comes from the sequence tagged site (STS) mapping of human CDC27 to the same yeast artificial chromosomes (YACs) positive for ITGB3. The estimated distance between ITGB3 and human CDC27 is less than 600 kb.

引用

页码：351 / 355

页数：5