Therapeutic plasma exchange as a life-saving therapy in a suspected case of autoimmune encephalitis: A case report from a tertiary health-care center

被引:4
|
作者
Pandey, Prashant Kumar [1 ]
Agarwal, Nitin [1 ]
Gupta, Manish [2 ]
机构
[1] Jaypee Hosp, Dept Transfus Med, Sect 128, Noida 201304, Uttar Pradesh, India
[2] Jaypee Hosp, Dept Neurol, Noida, Uttar Pradesh, India
来源
ASIAN JOURNAL OF TRANSFUSION SCIENCE | 2018年 / 12卷 / 02期
关键词
Autoimmune encephalitis; corticosteroid; intravenous immunoglobulins; therapeutic plasma exchange;
D O I
10.4103/ajts.AJTS_112_17
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In half of the suspected autoimmune encephalitis (AIE) patients, no antibodies are identified despite extensive investigation. Therapeutic plasma exchange (TPE) is a potential first-line therapy for various subtypes of AIE. Here, we present a case of autoantibody-negative-suspected AIE, managed successfully with TPE after patient showed no response to steroids. A total of 5 sessions of TPE was done. One standard TPE procedure session was 1.2-1.5 plasma volume exchanges using 5% albumin as a replacement fluid. After five sessions, patient's clinical condition improved significantly, and a repeated magnetic resonance imaging after 5th cycle of TPE revealed a reduction in the areas of signal alteration. This was suggestive of regression of disease. Patient was discharged on 10th day of hospital admission. With early suspicion even in the absence of detectable autoantibodies, TPE plays an important role in the management of encephalitis.
引用
收藏
页码:173 / 175
页数:3
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