AN ANALYSIS OF 2-PERIOD CROSSOVER DESIGNS WITH CARRY-OVER EFFECTS

被引：23
|
作者：
LAIRD, NM
SKINNER, J
KENWARD, M
机构：
[1] ABT ASSOCIATES INC,CAMBRIDGE,MA 02138
[2] UNIV READING, DEPT APPL STAT,READING RG6 2AN,ENGLAND
来源：
STATISTICS IN MEDICINE | 1992年 / 11卷 / 14-15期
关键词：
D O I：
10.1002/sim.4780111415
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The crossover design is a type of longitudinal study with subjects receiving different treatments in different time periods. When carry-over effects are absent, the usual crossover design is structured so that all the information about treatment effects is contained in the within-subject contrasts; standard analyses are based on these within-subject contrasts and ignore any between-subject information. With carry-over effects present these standard analyses can be very inefficient, especially for suboptimal designs. We describe alternative approaches based on methods for the analysis of longitudinal data.
引用
收藏
页码：1967 / 1979
页数：13
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