ANTIMALARIAL ACTIVITY AND CYTOTOXICITY OF EVODIA-FATRAINA STEM BARK EXTRACTS

被引：10
|
作者：
RATSIMAMANGAURVERG, S
RASOANAIVO, P
RAKOTORATSIMAMANGA, A
LEBRAS, J
RAMILIARISOA, O
SAVEL, J
COULAUD, JP
机构：
[1] INST MALGACHE APPL, ANTANANARIVO 101, MADAGASCAR
[2] HOP CLAUDE BERNARD, INST MED & EPIDEMIOL TROP & AFRICAINES, DEPT BIOL PARASITAIRE,INSERM,U13, F-75877 PARIS, FRANCE
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 1991年 / 33卷 / 03期
关键词：
EVODIA-FATRAINA; ANTIMALARIAL ACTIVITY; MADAGASCAR; PLASMODIUM;
D O I：
10.1016/0378-8741(91)90082-O
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Stem bark extracts of Evodia fatraina (Rutaceae) were tested for antimalarial activity in vitro on Plasmodium falciparum using an isotopic semi-microtest and in vivo on Plasmodium berghei in mice. Ethyl acetate extract showed moderate antimalarial activity in vitro (IC50 = 8.5-mu-g ml-1). However, ethanolic extract exhibited significant potency in vivo (65% suppression of parasitaemia). Moreover, low toxicity against HeLa cells and L 929 fibroblasts was observed with ethanolic extract (IC50 = 95-mu-g ml-1 and 60-mu-g ml-1, respectively).
引用
收藏
页码：231 / 236
页数：6
相关论文
共 50 条
  • [41] ANTIFUNGAL ACTIVITY OF BARK EXTRACTS OF CONIFERS
    MORI, M
    AOYAMA, M
    DOI, S
    KANETOSHI, A
    HAYASHI, T
    HOLZ ALS ROH-UND WERKSTOFF, 1995, 53 (02) : 81 - 82
  • [42] THE ANTIMALARIAL ACTIVITY OF SPATHODEA-CAMPANULATA STEM BARK EXTRACT ON PLASMODIUM-BERGHEI BERGHEI IN MICE
    MAKINDE, JM
    AMUSAN, OOG
    ADESOGAN, EK
    PLANTA MEDICA, 1988, (02) : 122 - 125
  • [43] ANTINOCICEPTIVE AND ANTIINFLAMMATORY ACTIVITY OF THE HEXANE AND ETHYL ACETATE EXTRACTS OF CROTON MACROSTACHYUS STEM BARK
    Mbiantcha, Marius
    Nguelefack, Telesphore Benoit
    Ndontsa, Blanche Laure
    Tane, Pierre
    Kamanyi, Albert
    RHEUMATOLOGY, 2011, 50 : ii8 - ii8
  • [44] Antiplasmodial activity of total alkaloids and flavonoids of stem bark extracts of Enantia chlorantha in mice
    Abubakar A.
    Ahmad N.S.
    Akanya H.O.
    Abdulkadir A.
    Abubakar A.N.
    Comparative Clinical Pathology, 2020, 29 (4) : 873 - 881
  • [45] ANTIPLASMODIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF EXTRACTS FROM THE ROOTS AND STEM BARK OF JATROPHA CURCAS
    Sani, Abubakar
    Kabir, Aisha
    ACTA CHEMICA IASI, 2023, 31 (01) : 63 - 78
  • [46] Cognitive enhancing effects and anticholinesterase activity of stem bark and leaf extracts of Prunus africana
    Ngai, David N.
    Kibiti, Cromwell M.
    Ngugi, Mathew Piero
    HELIYON, 2022, 8 (12)
  • [47] Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides
    Shuaibu, Mohammed N.
    Wuyep, Ponchang T. A.
    Yanagi, Tetsuo
    Hirayama, Kenji
    Ichinose, Akitoyo
    Tanaka, Takashi
    Kouno, Isao
    PARASITOLOGY RESEARCH, 2008, 102 (04) : 697 - 703
  • [48] Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides
    Mohammed N. Shuaibu
    Ponchang T. A. Wuyep
    Tetsuo Yanagi
    Kenji Hirayama
    Akitoyo Ichinose
    Takashi Tanaka
    Isao Kouno
    Parasitology Research, 2008, 102 : 697 - 703
  • [49] Antimicrobial activity and phytochemical screening of stem bark extracts from Jatropha curcas (Linn)
    Igbinosa, O. O.
    Igbinosa, E. O.
    Aiyegoro, O. A.
    AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2009, 3 (02): : 58 - 62
  • [50] ANTIMICROBIAL ACTIVITY OF EXTRACTS AND TOPICAL PRODUCTS OF THE STEM BARK OF SPATHODEA CAMPANULATA FOR WOUND HEALING
    Ofori-Kwakye, K.
    Kwapong, A. A.
    Adu, F.
    AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES, 2009, 6 (02) : 168 - 174
12345