HUMAN OLIGODENDROCYTES ARE SUSCEPTIBLE TO CYTOLYSIS BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I-RESTRICTED LYMPHOCYTES

被引：41
|
作者：
RUIJS, TCG [1 ]
FREEDMAN, MS [1 ]
GRENIER, YG [1 ]
OLIVIER, A [1 ]
ANTEL, JP [1 ]
机构：
[1] MCGILL UNIV,DEPT NEUROL & NEUROSURG,MONTREAL H3A 2T5,QUEBEC,CANADA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 27卷 / 2-3期
基金：
英国医学研究理事会;
关键词：
(Human); Cytotoxic lymphocyte; Multiple sclerosis; Oligodendrocyte;
D O I：
10.1016/0165-5728(90)90058-U
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The majority of human oligodendrocytes in enriched glial cell cultures expresses class I major histocompatibility complex (MHC) antigens. We used a 51Cr release assay to study the susceptibility of oligodendrocyte-enriched glial cells to MHC-restricted and non-restricted immune-mediated cytolysis. Mitogen-activated mononuclear cells induced significant lysis in a lectin-dependent cytotoxicity assay. Mononuclear cells allo-activated in a one-way mixed lymphocyte culture with E- cells from the glial cell donor induced a significantly higher degree of oligodendrocyte cytolysis than mononuclear cells activated with E- cells bearing MHC-class I antigens discordant with the glia. Cytolysis by alloactivated unfractionated lymphocytes and by purified CD8+ lymphocytes was reduced by an anti-class I antibody (W6/32). Our findings suggest that human oligodendrocytes can be susceptible targets for MHC class I-restricted lysis. © 1990.
引用
收藏
页码：89 / 97
页数：9
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