TRANSFER OF GENES TO HUMANS - EARLY LESSONS AND OBSTACLES TO SUCCESS

被引：897
作者：
CRYSTAL, RG
机构：
[1] Department of Medicine, New York Hospital-Cornell Medical Center, New York, NY 10021
[2] Division of Pulmonary and Critical Care Medicine, New York Hospital-Cornell Medical Center, New York, NY 10021
来源：
SCIENCE | 1995年 / 270卷 / 5235期
关键词：
D O I：
10.1126/science.270.5235.404
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Enough information has been gained from clinical trials to allow the conclusion that human gene transfer is feasible, can evoke biologic responses that are relevant to human disease, and can provide important insights into human biology. Adverse events have been uncommon and have been related to the gene delivery strategies, not to the genetic material being transferred. Human gene transfer still faces significant hurdles before it becomes an established therapeutic strategy. However, its accomplishments to date are impressive, and the logic of the potential usefulness of this clinical paradigm continues to be compelling.
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页码：404 / 410
页数：7
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