HIV-INHIBITORY NATURAL-PRODUCTS .11. COMPARATIVE-STUDIES OF SULFATED STEROLS FROM MARINE-INVERTEBRATES

被引：65
|
作者：
MCKEE, TC [1 ]
CARDELLINA, JH [1 ]
RICCIO, R [1 ]
DAURIA, MV [1 ]
IORIZZI, M [1 ]
MINALE, L [1 ]
MORAN, RA [1 ]
GULAKOWSKI, RJ [1 ]
MCMAHON, JB [1 ]
BUCKHEIT, RW [1 ]
SNADER, KM [1 ]
BOYD, MR [1 ]
机构：
[1] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,DRUG DISCOVERY RES & DEV LAB,BLDG 1052,ROOM 121,FREDERICK,MD 21702
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 06期
关键词：
D O I：
10.1021/jm00032a012
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values- of 3-13 muM against HIV-1 (RF) and 2-8 muM against HIV-2 (CBL20). Those compounds which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.
引用
收藏
页码：793 / 797
页数：5
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