EFFECT OF INTERLEUKIN-6 ON CELL-PROLIFERATION OF FRTL-5 CELLS

被引:11
|
作者
NISHIYAMA, S [1 ]
TAKADA, K [1 ]
TADA, H [1 ]
TAKANO, T [1 ]
AMINO, N [1 ]
机构
[1] OSAKA UNIV,SCH MED,DEPT LAB MED,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN
关键词
D O I
10.1006/bbrc.1993.1416
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We studied the effects of interleukin-6(IL-6) on DNA synthesis and cyclic AMP production in rat thyroid FRTL-5 cells. When cells were incubated with IL-6 in the presence or absence of IGF-I, cell proliferation was not observed. By contrast, IL-6 stimulated DNA synthesis in a dose dependent manner when TSH was added concomitantly. On the other hand, IL-6 did not modulate the cAMP accumulation in the presence or absence of TSH. These data demonstrate that, like IGF-I, IL-6 may be able to act as a growth factor through activation of a mitogenic signal transduction pathway different from A-kinase in FRTL-5 cells. © 1993 Academic Press.
引用
收藏
页码:319 / 323
页数:5
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