EFFICACY OF MOXIDECTIN ORAL GEL AGAINST ONCHOCERCA-CERVICALIS-MICROFILARIAE

被引：13

作者：

MONAHAN, CM ^{[1
]}

CHAPMAN, MR ^{[1
]}

FRENCH, DD ^{[1
]}

KLEI, TR ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,CTR AGR,LOUISIANA AGR EXPT STN,DEPT VET SCI,BATON ROUGE,LA 70803

来源：

JOURNAL OF PARASITOLOGY | 1995年 / 81卷 / 01期

关键词：

D O I：

10.2307/3284021

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

During a series of dose-titration experiments designed to evaluate the efficacy of moxidectin oral gel against equine gastrointestinal parasites, infection with Onchocerca cervicalis was diagnosed in 25 of 82 ponies prior to treatment. Microfilariae were identified in full-thickness skin biopsies taken from the ventral midline. Treatment with moxidectin in single doses of 300, 400, or 500 mu g/kg of body weight was 100% effective in eliminating microfilariae from 20 skin biopsies taken 14 days posttreatment, whereas 5 microfilaria-positive ponies in 2 control groups remained positive following placebo treatment. No adverse reaction was seen in any pony following treatment with moxidectin or the vehicle control.

引用

页码：117 / 118

页数：2

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