DIFFERENTIAL INFLUENCE OF DNA SUPERCOILING ON IN-VIVO STRENGTH OF PROMOTERS VARYING IN STRUCTURE AND ORGANIZATION IN ESCHERICHIA-COLI

被引：4

作者：

JYOTHIRMAI, G ^{[1
]}

MISHRA, RK ^{[1
]}

机构：

[1] CTR CELLULAR & MOLEC BIOL, HYDERABAD 500007, INDIA

来源：

FEBS LETTERS | 1994年 / 340卷 / 03期

关键词：

TRANSCRIPTION; PROMOTER; DNA SUPERCOILING; ESCHERICHIA COLI;

D O I：

10.1016/0014-5793(94)80135-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA supercoiling is known to influence promoter activity in vitro and in vivo in a promoter-dependent manner in prokaryotes. In order to investigate how topology may influence promoter function, we have studied two kinds of promoter variants, (i) where only the spacer region is altered, and (ii) where the same promoter is tandemly repeated in either the same or opposite orientation. These promoters respond very differently to alterations in DNA supercoiling, suggesting that the overall structure of the promoter and its context contribute to the differential response to alterations in supercoiling in vivo.

引用

页码：189 / 192

页数：4

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