ESTABLISHMENT AND CHARACTERIZATION OF A CHILDHOOD PRE-B ACUTE LYMPHOBLASTIC-LEUKEMIA CELL-LINE, PER-278, WITH CHROMOSOME TRANSLOCATIONS T(1-19) AND T(1-9)

被引：10
|
作者：
KEES, UR [1 ]
LUKEIS, R [1 ]
FORD, J [1 ]
WILLOUGHBY, MLN [1 ]
GARSON, OM [1 ]
机构：
[1] ST VINCENTS HOSP,DEPT CYTOGENET,FITZROY,VIC 3065,AUSTRALIA
来源：
CANCER GENETICS AND CYTOGENETICS | 1990年 / 46卷 / 02期
关键词：
D O I：
10.1016/0165-4608(90)90105-J
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cell line PER-278 was established from a bone marrow sample of a 10-year-old boy diagnosed with pre-B acute lymphoblastic leukemia (ALL). PER-278 cells show the pre-B phenotype, express cytoplasmic Ig, and exhibit two translocations: t(1;19)(q23;p13) and t(1;9)(q23;p13). Assessment of the immunoglobulin rearrangements confirmed the clonal origin of cell line PER-278, and comparison with the patient's leukemic cells showed an identical pattern: loci involved at the breakpoint on chromosome 1 code for the oncogene SKI and for the Fc receptor II and on chromosome 19 for the insulin receptor. The t(1;19) may contribute to the malignant transformation in leukemic cells of pre-B phenotype. © 1990.
引用
收藏
页码：201 / 208
页数：8
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