SEROLOGICALLY ACTIVE CLINICALLY QUIESCENT SYSTEMIC LUPUS-ERYTHEMATOSUS - DISCORDANCE BETWEEN CLINICAL AND SEROLOGIC FEATURES

被引：156

作者：

GLADMAN, DD ^{[1
]}

UROWITZ, MB ^{[1
]}

KEYSTONE, EC ^{[1
]}

机构：

[1] UNIV TORONTO, WELLESLEY HOSP, RHEUMAT DIS UNIT 651A, TORONTO, ONTARIO, CANADA

来源：

AMERICAN JOURNAL OF MEDICINE | 1979年 / 66卷 / 02期

关键词：

D O I：

10.1016/0002-9343(79)90529-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The significance of abnormal serologic tests in systemic lupus erythematosus (SLE) in the absence of active clinical disease is unclear. In this report we describe a group of 14 patients with SLE in whom a discordance between clinical and serologic features was apparent. These patients had persistently positive lupus erythematosus preparations and antinuclear antibody tests, low serum complement levels and high levels of DNA binding. Their lymphocyte response to concanavalin A (Con A) mitogen was suppressed. They have been asymptomatic and have remained untreated for a mean of four and a quarter years. © 1979.

引用

页码：210 / 215

页数：6

共 34 条

[1] IMMUNOLOGY OF DNA .3. CRITHIDIA-LUCILIAE, A SIMPLE SUBSTRATE FOR DETERMINATION OF ANTI-DSDNA WITH IMMUNOFLUORESCENCE TECHNIQUE [J].

AARDEN, LA ;

DEGROOT, ER ;

FELTKAMP, TEW .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1975, 254 :505-515

[2]

BALDWIN DS, 1977, AM J MED, V62, P12, DOI 10.1016/0002-9343(77)90345-X

[3]

Brunner C M, 1975, Bull Rheum Dis, V26, P854

[4]

CARR RI, 1975, J RHEUMATOL, V2, P178

[5]

COHEN A S, 1971, Bulletin on the Rheumatic Diseases, V21, P643

[6] CORRELATION BETWEEN LEVELS OF DNA ANTIBODIES AND CLINICAL DISEASE ACTIVITY IN SLE - RETROSPECTIVE EVALUATION [J].

DAVIS, P ;

PERCY, JS ;

RUSSELL, AS .

ANNALS OF THE RHEUMATIC DISEASES, 1977, 36 (02) :157-159

[7]

DAVIS P, 1977, CLIN EXP IMMUNOL, V28, P226

[8] IMMUNOLOGICAL EVENTS PRECEDING CLINICAL EXACERBATION OF SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

EPSTEIN, WV .

AMERICAN JOURNAL OF MEDICINE, 1973, 54 (05) :631-636

[9]

FRIES JF, 1975, CLIN ANAL, V6, P143

[10]

FRIOU GJ, 1972, ARTHRITIS ALLIED CON, P172

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