EXPRESSION OF A NOVEL FAMILY OF EPITOPES ON SMALL INTESTINAL MUCINS IN COLORECTAL CANCERS, ADJACENT AND REMOTE MUCOSA

被引：7
|
作者：
PILBROW, SJ
HERTZOG, PJ
PINCZOWER, GD
LINNANE, AW
机构：
[1] MONASH UNIV,CTR MOLEC BIOL & MED,CLAYTON,VIC 3168,AUSTRALIA
[2] MONASH UNIV,DEPT BIOCHEM,CLAYTON,VIC 3168,AUSTRALIA
来源：
TUMOR BIOLOGY | 1992年 / 13卷 / 5-6期
关键词：
MUCIN; COLORECTAL CANCER; TRANSITIONAL MUCOSA; MONOCLONAL ANTIBODY; IMMUNOHISTOCHEMISTRY; ONCOFETAL; IMMUNOCHEMISTRY;
D O I：
10.1159/000217774
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We describe the production, immunochemical and immunohistochemical characterization of monoclonal antibodies (MAbs) raised against the oncofetal small intestinal mucin antigen (SIMA). Four MAbs, reacting with distinct neuraminidase-sensitive SIMA epitopes, were shown to define a novel differentiation-associated relationship of SIMA epitopes within the normal small intestinal villus. Using Swiss rolls of 15 entire colorectal cancer resections, inappropriate expression of SIMA epitopes was detected in all cancers, in adjacent transitional mucosa and remote morphologically normal mucosa, extending as far as resection margins (73%). SIMA expression, whether preexisting or reactive to the tumor, may predispose to malignant change and tumor recurrence.
引用
收藏
页码：251 / 267
页数：17
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