IDENTIFICATION OF INSECTICIDAL PEPTIDES FROM VENOM OF THE TRAP-DOOR SPIDER, APTOSTICHUS-SCHLINGERI (CTENIZIDAE)

被引：43
|
作者：
SKINNER, WS
DENNIS, PA
LI, JP
QUISTAD, GB
机构：
[1] Sandoz Agro, Inc., Research Division, Palo Alto, CA 94304
来源：
TOXICON | 1992年 / 30卷 / 09期
关键词：
D O I：
10.1016/0041-0101(92)90049-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nine insecticidal peptides were isolated from the venom of the trap-door spider, Aptostichus schlingeri. Seven of these toxins cause flaccid paralysis of insect larvae within 10 min of injection and all were lethal within 24 hr. The complete amino acid sequences (32-76 residues) of six peptides are presented. The identified peptides contain three or four disulfide bonds and the larger peptides (74-76 residues) are quite similar in sequence with carboxyl termini as free acids, not amidated.
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页码：1043 / 1050
页数：8
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